Ipshita Zutshi combined optogenetic/pharmacogenetic local and upstream inactivation of CA1. She showed that CA1 induce and maintain coordinated cell assemblies with minimal reliance on its inputs from CA3 and EC.
Pyramidal cells and GABAergic interneurons fire together in balanced cortical networks. In contrast to this general rule, we describe a distinct neuron type expressing ID2 and Nkx2.1, whose spiking activity is anti-correlated with all principal cells.
Sara Mederos et al show the astrocytes as a hub for controlling inhibition in cortical circuits, providing a novel pathway for information processing and goal-directed behaviors.